| MBT | 500 | DNA and Proteins | 3 hours. | DNA Replication, transcription, translation and post-translational modifications. Genome structure. Viruses. Bioinformatics and microarrays. Protein structure. Enzyme mechanisms. Biochemical pathways, and regulation of biochemical pathways. Recommended background: Basic undergraduate general and organic chemistry, biology, physics, and math. |
| MBT | 501 | Cell Biology | 2 hours. | Cellular membranes structure and transport, protein localization and vesicular transport, cell signaling, cell adhesion, junction and cell-matrix attachment, stem cells and tissue renewals, cell cycle control, apoptosis, and cancer. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. Recommended background: Basic undergraduate general and organic chemistry, and basic (general) biology. |
| MBT | 502 | Immunotechnology, Microbiology and Cellular Therapy | 3 hours. | Covers antibody production principals, clinical uses of antibodies, fermentation and bioremediation and protein production principals, cellular and stem cell therapies, bioterrorism control, containment and eradication. Prerequisite(s): MBT 500 and MBT 501. |
| MBT | 503 | Pharmacology, Toxicology and Clinical Trials | 3 hours. | Basic pharmacology, drug-receptor interactions. Basic toxicology. Drug development cycle (Preclinical work, Phase I, II, III). Design, implementation and evaluation of clinical trials. IRB issues. Ethical conduct of clinical trials. Prerequisite(s): MBT 500 and MBT 501. |
| MBT | 504 | Principles and Techniques in Protein Biochemistry | 3 hours. | Protein structure and structure/function relationships, protein expression, purification and characterization, chemical analysis and modification of proteins, identifications of protein interactions and protein chips. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 505 | Principles and Techniques in Molecular Biology | 3 hours. | Includes underlying theory of molecular biology and its applications. Laboratory sessions will provide hands on experience in molecular biology techniques. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 506 | Principles and Techniques in Immunology | 3 hours. | Principles and methodologies involved in antigen preparation and presentation, antibody production and purification, isolation and immortalization of immune cells, immunohistochemical analyses and assays for complements and cytokines. Animals used in instruction. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 510 | Ethics in Medical Biotechnology | 2 hours. | Rationale for making ethical decisions, review of existing guidelines, considerations of the use of adult and embryonic stem cells, ethical issues on animal research, conflict of interest and misconduct in research and business. Prerequisite(s): MBT 500 and MBT 501 and MBT 502 and MBT 503; or consent of the instructor. |
| MBT | 511 | Statistics for Biotechnology Research | 3 hours. | Reinforce an understanding of basic statistical concepts and provide basic skills in creating, manipulating, and analyzing datasets using commonly available software such as SPSS, Excel, and Minitab. Credit is not given for MBT 511 if the student has credit for BSTT 400 or NUSC 525. Extensive computer use required. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. Recommended background: Basic undergraduate statistics. |
| MBT | 513 | Research Planning, Design and Execution | 1 hours. | Presentation of the basics of planning, designing and executing a research plan. Students prepare a project plan and defend the plan to a faculty panel and peers. Satisfactory/Unsatisfactory grading only. May be repeated to a maximum of 2 hours. |
| MBT | 520 | Biotechnology Product Development: Concepts, Practice and Regulatory Issues | 2 hours. | Product development and commercialization processes. Product life cycles, program management basics. Intellectual property. Regulatory affairs issues: GLP, product registration, GMP, documentation, validation, FDA inspections. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 521 | Techniques and Processes in Biotechnology | 3 hours. | Preparation and isolation of antibodies, basics of cell culture, recombinant DNA techniques, techniques of protein production and engineering and examples of cloning. Basics of GLP and practical experience in applications of GLP. Prerequisite(s): MBT 500 and MBT 501. Course Schedule Information: To be properly registered, students must enroll in one Discussion and one Laboratory. |
| MBT | 522 | Applied Medical Biotechnology | 2 hours. | The principles and methodologies used in commercial lab assays will be analyzed and their strengths and weaknesses discussed. An array of hospital/clinical techniques will be reviewed via lecture/demonstration in typical application venue. Prerequisite(s): MBT 500 and MBT 501 and MBT 520. |
| MBT | 523 | Biotechnology Engineering | 2 hours. | Engineering aspects of large-scale cell culture: methodologies, types of production equipment, process sensing and control, harvesting, separation and purification. Sterilization, aseptic processing, filling and finishing steps. QA/QC. Field trips required. Prerequisite(s): Completion of the first year of the MS in Medical Biotechnology program. |
| MBT | 524 | Applied Microbiology | 2 hours. | Review of the basic elements of microbiology; laboratory training in culturing and identification of microbes; antibiotic susceptibility testing and applications of microbiology in biotechnology and pharmaceutical industry. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 525 | Drug Design and Discovery | 1 hours. | Lead substances, molecular recognition, bioinformatics and combinatorial chemistry in drug design. Enzymes / receptors as design targets, screening of natural products, high throughput assays and preclinical studies. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 526 | Safety Assessment of Drugs and Devices | 1 hours. | Course will focus on the technical processes and legal requirements of pre - clinical safety assessment of drugs and devices with some discussion of clinical assessment practices. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 527 | Design and Execution of Clinical Trials | 1 hours. | Presentation of basic concepts of clinical trials: " the question", the study population, basic study design, randomness, blindedness, sample sizing, baseline assessment, data collection and QC.Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 528 | Basic Bioinformatics | 2 hours. | Introduction to bioinformatics covering biological databases, gene prediction, sequence alignment, phylogenetic analysis, structural bioinformatics, genomics, functional genomics and proteomics. Extensive computer use required. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 591 | Departmental Seminar in Medical Biotechnology | 1 TO 4 hours. | Lecture series by invited speaker or advanced students with lectures on topics of current or developing interest in medical biotechnology. Satisfactory/Unsatisfactory grading only. May be repeated. Prerequisite(s): Approval of the department. |
| MBT | 594 | Special Topics in Medical Biotechnology | 1 TO 4 hours. | Lectures and demonstrations of new topics of significance in medical biotechnology that are not covered in existing courses. May be repeated. Prerequisite(s): Consent of the instructor. |
| MBT | 595 | Student Seminar in Medical Biotechnology | 1 TO 2 hours. | Students are taught how to write and present literature research/review papers on topics directly related to medical biotechnology. Satisfactory/Unsatisfactory grading only. Prerequisite(s): Graduate standing in Medical Biotechnology program or approval of the Department of Biomedical Sciences at College of Medicine - Rockford. |
| MBT | 596 | Independent Study in Medical Biotechnology | 1 TO 4 hours. | Independent and individual study of a topic in medical biotechnology. Usually involves extensive literature research culminating in a review paper or hypothesis/conclusion argument paper. May be repeated to a maximum of 4 hours if topics vary. Students may register in more than one section per term. Prerequisite(s): Completion of the first year of the MS in Medical Biotechnology program, approval of the department, and approval of a faculty mentor. The student also should have completed core or elective courses in the degree sequence that introduce the topic of independent study or have verifiable outside knowledge. |
| MBT | 597 | Master's Project Research | 0 TO 16 hours. | A project-based internship at a biotechnology company or a research laboratory at the College of Medicine in Rockford. Students will gain on-the-job experience in designing and conducting experiments, evaluating results, and reporting to supervisors. Satisfactory/Unsatisfactory grading only. May be repeated. Prerequisite(s): Student should have approval of the graduate committee to commence research and the agreement of faculty and industrial mentors along with a written agreement for research activity from the host company. |
| MBT | 598 | Master's Thesis Research | 0 TO 16 hours. | Master's thesis research conducted at the College of Medicine in Rockford under faculty supervision. Satisfactory/Unsatisfactory grading only. May be repeated. Prerequisite(s): Completion of the first year of the program and consent of the instructor. |