| BIOE | 402 | Medical Technology Assessment | 2 OR 3 hours. | Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor. |
| BIOE | 405 | Atomic and Molecular Nanotechnology | 3 OR 4 hours. | Nanoscale structures and phenomena. Simulation methods for nano systems, and molecular assemblies. Molecular building blocks, scanning probe and atomic force microscopy, quantum mechanical phenomena. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Senior standing or above. Recommended background: Engineering or physical science major. |
| BIOE | 406 | Regulation and Manufacturing Practices in Medical Technology | 2 OR 3 hours. | Bioentrepreneur course. Product requirement definition, FDA, quality system regulation, community Europe, medical device directive, role of management, United States pharmacopoeia, toxicity testing, hazard analysis, risk assessment, import/export. 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor. |
| BIOE | 407 | Pattern Recognition I | 3 OR 4 hours. | The design of automated systems for detection, recognition, classification and diagnosis. Parametric and nonparametric decision-making techniques. Applications in computerized medical and industrial image and waveform analysis. Same as ECE 407. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): MATH 220. |
| BIOE | 408 | Medical Product Development | 2 OR 3 hours. | Bioentrepreneur course. Major stages of medical product development (investigative, feasibility, development, commercialization, maturation and growth), regulatory issues, product performance, failure mode and effect analysis, hazard analysis. 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor. |
| BIOE | 410 | FDA and ISO Requirements for the Development and Manufacturing of Medical Devices | 3 OR 4 hours. | FDA Performance Standard for General Medical Devices for manufacturing and development engineers. Product requirement definition, design control, hazard analysis, failure mode and effect analysis, regulatory submission, product tests, ISO 9001. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100 and BIOE 250. Recommended background: Junior standing or above. |
| BIOE | 415 | Biomechanics | 3 OR 4 hours. | Use of rigid and deformable body statics and rigid body dynamics to analyze various aspects of the human musculoskeletal system. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 201 and ME 210; and BIOS 430 or BIOS 443 or BIOS 484 or BIOS 485. |
| BIOE | 420 | Introduction to Field and Waves in Biological Tissues | 3 OR 4 hours. | Principles of electromagnetic and ultrasonic interaction with biological systems; characterization of biological materials; diagnostic and therapeutic uses; and techniques of dosimetry and measurement. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): ECE 310. |
| BIOE | 421 | Biomedical Imaging | 3 OR 4 hours. | Introduction to engineering and scientific principles associated with X-ray, magnetic resonance, ultrasound, computed tomographic and nuclear imaging. 3 undergraduate hours. 4 graduate hours. Extensive computer use required. Prerequisite(s): MATH 210 and PHYS 142. |
| BIOE | 430 | Bioinstrumentation and Measurements I | 3 OR 4 hours. | Theory and application of instrumentation used for physiological and medical measurements. Characteristics of physiological variables, signal conditioning devices and transducers. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100; and ECE 115 or ECE 210 or ECE 225; and BIOE 310 or ECE 310 or ME 312. |
| BIOE | 431 | Bioinstrumentation and Measurement Laboratory | 2 hours. | Practical experience in the use of biomedical instrumentation for physiological measurements. Prerequisite(s): Credit or concurrent registration in BIOE 430. |
| BIOE | 432 | Bioinstrumentation and Measurements II | 3 OR 4 hours. | Principles of bioinstrumentation for the assessment of physiological function and therapeutic intervention. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 430. |
| BIOE | 433 | Bioinstrumentation and Measurements II Laboratory | 1 hours. | Laboratory experiments using instruments to assess physiological function. Prerequisite(s): Credit or concurrent registration in BIOE 432. |
| BIOE | 439 | Biostatistics II | 4 hours. | Statistical treatment of data, model estimation, and inference are treated in a framework of biological experiments and attributes of data generated from such experiments. Credit is not given for BIOE 439 if the student has credit for BSTT 400. Extensive computer use required. Prerequisite(s): MATH 210 and CS 108; and consent of the instructor. Recommended background: Knowledge of MATLab. |
| BIOE | 440 | Biological Signal Analysis | 3 OR 4 hours. | Analysis of signals of biological origin. Transient signals. Stability analysis. Control. Probabilities, stochastic processes. Medical applications. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): MATH 210 and senior or graduate standing. |
| BIOE | 450 | Molecular Biophysics of the Cell | 4 hours. | Introduction to force, time energies at nanometer scales; Boltzmann distribution; hydrodynamic drag; Brownian motions; DNA, RNA protein structure and function; sedimentation; chemical kinetics; general aspects of flexible polymers. Same as PHYS 450. Prerequisite(s): PHYS 245 or the equivalent. |
| BIOE | 452 | Biocontrol | 3 OR 4 hours. | Considers the unique characteristics of physiological systems using the framework of linear systems and control theory. Static and dynamic operating characteristics, stability, and the relationship of pathology to control function. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): ECE 310; and either BIOS 442 or BIOS 443. |
| BIOE | 455 | Introduction to Cell and Tissue Engineering | 3 OR 4 hours. | Foundation of cell and tissue engineering covering cell technology, construct technology, and cell-substrate interactions. Emphasis in emerging trends and technologies in tissue engineering. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 260; and credit or concurrent registration in BIOE 430 or BIOS 443 or BIOS 484 or BIOS 485. |
| BIOE | 456 | Cell and Tissue Engineering Laboratory | 2 hours. | Includes polymer scaffold fabrication, microstamping biomolecules, cellular adhesion and proliferation assays, and immo/fluorescent tagging. Prerequisite(s): Credit or concurrent registration in BIOE 455; or consent of the instructor. |
| BIOE | 460 | Materials in Bioengineering | 3 OR 4 hours. | Analysis and design considerations of problems associated with prostheses and other implanted biomedical devices. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 260; and BIOS 220 or BIOS 222 or BIOS 240 BIOS 286 or BIOS 352. |
| BIOE | 465 | Metabolic Engineering | 3 OR 4 hours. | Quantitative descriptions of biochemical networks; modeling, control, and design of metabolic pathways to achieve industrial and medical goals. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310 or ECE 310 or ME 312; or consent of the instructor. |
| BIOE | 470 | Bio-Optics | 3 OR 4 hours. | Physical principles and instrumentation relevant to the use of light in biomedical research. Several current and developing clinical applications are explored. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): PHYS 142. |
| BIOE | 472 | Models of the Nervous System | 3 OR 4 hours. | Mathematical models of neural excitation and nerve conduction, stochastic models and simululation of neuronal activity, models of neuron pools and information processing, models of specific neural networks. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310 or ECE 310 or ME 312; and credit or concurrent registration in BIOS 484 or BIOS 485. |
| BIOE | 475 | Neural Engineering I: Introduction to Hybrid Neural Systems | 3 OR 4 hours. | Modeling and design of functional neural interfaces for in vivo and in vitro applications, electrodes and molecular coatings, neural prostheses and biopotential control of robotics. Same as BIOS 475. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 472; or consent of the instructor. |
| BIOE | 476 | Neural Engineering I Laboratory | 2 hours. | Hands-on experience with computational and experimental models of engineered neural systems, with emphasis on neuroprostheses and biosensors. Animals used in instruction. Prerequisite(s): Credit or concurrent registration in BIOE 475. |
| BIOE | 480 | Introduction to Bioinformatics | 3 OR 4 hours. | Computational analysis of genomic sequences and other high throughput data. Sequence alignment, dynamic programming, database search, protein motifs, cDNA expression array, and structural bioinformatics. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100 and CS 201; or consent of the instructor. |
| BIOE | 481 | Bioinformatics Laboratory | 2 hours. | How to use bioinformatics tools, including sequence alignment methods such as Blast, Fasta, and Pfam, as well as structural bioinformatics tools, such as Rasmol and CastP. Extensive computer use required. Prerequisite(s): Credit or concurrent registration in BIOE 480; and senior standing or above; and consent of the instructor. |
| BIOE | 482 | Introduction to Optimization Methods in Bioinformatics | 3 OR 4 hours. | The objectives are to provide the students with a basis for understanding principles of the optimization methods and an insight on how these methods are used in bioinformatics. 3 undergraduate hours. 4 graduate hours. Extensive computer use required. Prerequisite(s): BIOS 100 and CS 201. |
| BIOE | 483 | Molecular Modeling in Bioinformatics | 3 OR 4 hours. | Basic structural and dynamics tools in protein structure prediction, structure comparison, function prediction, Monte Carlo and molecular dynamics simulations. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Grade of B or better in BIOE 480. |
| BIOE | 494 | Special Topics in Bioengineering | 1 TO 4 hours. | Special topics to be arranged. May be repeated. Students may register in more than one section per term. Prerequisite(s): Consent of the instructor. |
| BIOE | 500 | Interfacial Biosystems Engineering | 4 hours. | Advanced and detailed exposition of the fundamentals of biological systems using quantitative approaches. Areas of concentration include bioinformatics, cell and tissue engineering, and neuroengineering. Prerequisite(s): BIOS 442. |
| BIOE | 504 | Emerging Medical Technologies | 2 hours. | Investigates new and emerging medical technologies following the technical due diligence process, a methodical evaluation of strengths, weaknesses, opportunities and threats of the identified technology. Prerequisite(s): BIOE 401 or BIOE 402 or BIOE 403 or the equivalent. |
| BIOE | 505 | NanoBioTechnology | 4 hours. | Nanotechnology theory and applications in biology and medicine. Molecular simulations, combinatorial chemistry. Nanoscale structures, molecular building blocks, integrated nano-bio complexes. Positional and self-assembly, self-replication. Recommended background: Engineering or physical sciences. |
| BIOE | 514 | Biotransport | 4 hours. | Diffusion and flow in living systems. Blood rheology and flow. Microcirculation, oxygen transport, diffusive transport across membranes. Membrane structure; water, and ion flows, active transport. Same as CHE 514. Prerequisite(s): CHE 410 or consent of the instructor. |
| BIOE | 515 | Mechanics of the Human Spine | 4 hours. | Biomechanics as applied to the human spine. Spinal loading. Experimentation methods and modelling of intact ligamentous spine. Nature and treatment of adolescent idiopathic scoliosis. Thoracolumbar injuries. Prerequisite(s): BIOE 415 or the equivalent. |
| BIOE | 518 | Controlled Drug Delivery | 3 hours. | Controlled drug delivery systems utilizing polymers, synthesis of different types of devices, and the delivery expected from these devices, and mathematical modeling of delivery systems. Same as BPS 518. Prerequisite(s): MATH 220 or approval of the department. |
| BIOE | 521 | Imaging Systems for Biological Tissues | 4 hours. | Examination of major imaging systems using ionizing and nonionizing energy for characterization of biological tissues and physiological lesions. Prerequisite(s): BIOE 420. |
| BIOE | 522 | Principles of Polymeric Science and Engineering | 3 hours. | Intermediate polymer science, thermodynamics of polymer solutions, phase separations, MW determination, crystallization, elasticity, kinetics and processing. Same as BPS 522. Prerequisite(s): MATH 220 or consent of the instructor. |
| BIOE | 525 | Physiological and Cellular Effects of Biomechanical Forces | 4 hours. | Discuss how biomechanical forces are generated, the impact the forces have on cells and tissues, plus methods for studying them. Mechanisms by which cells may sense forces and transduce this information to the nucleus are also covered. Prerequisite(s): Consent of the instructor. |
| BIOE | 548 | Micro and Nanotechnology for Biomedical Applications | 4 hours. | This course covers selected topics in micro- and nano-technology underlying biomedical applications; topics include: microfabrication and nanofabrication; microfluidic processes; neuroMEMS; nanoscale structures as functional bio-interfaces. Prerequisite(s): PHYS 244. |
| BIOE | 550 | Principles of Cell and Tissue Engineering | 4 hours. | Introduction to tissue engineering. Presents principles of biomedical, biochemical, and biomaterials science applied to tissue engineered organ replacements, implantable medical devices, and drug delivery systems. Prerequisite(s): BIOS 442 or BIOS 443; and CEMM 260. Recommended background: A course in cell biology. |
| BIOE | 552 | Advanced Biocontrol | 4 hours. | Modeling and analysis of physiological systems including such topics as adaptive control, statistical analysis error signal analysis and the characteriszation of individual neural control elements. Prerequisite(s): BIOE 452. |
| BIOE | 560 | Processing and Properties of Structural Biomaterials | 4 hours. | Considers the inter-relationships between atomic bonding, atomic/molecular structure and material processing to provide a fundamental understanding of the properties and performance of advanced biomaterials. Prerequisite(s): CEMM 260. Recommended background: Credit in BIOE 460. |
| BIOE | 575 | Neural Engineering II - Neural Coding | 4 hours. | Analytical techniques and models used to assess and predict neural activity. Emphasis on information coding in sensory systems. Prerequisite(s): Consent of the instructor. Recommended background: Working knowledge of Matlab. |
| BIOE | 576 | Sensory Prostheses Engineering | 4 hours. | Critical review of existing and emerging prosthetic devices for sensory systems damaged by trauma or disease. Technology and information flow in hybrid systems are emphasized. Prerequisite(s): BIOE 475 and BIOS 442; or consent of the instructor. |
| BIOE | 579 | Neural and Neuromuscular Prostheses | 4 hours. | Neuromuscular electrical stimulation for ambulation by paraplegics, of upper limb in tetraplegics, of vocal cord and breathing functions, stimulation of bladder, cochlea, retina, and visual cortex. Prerequisite(s): Consent of the instructor. |
| BIOE | 580 | Principles of Bioinformatics | 4 hours. | Bioinformatics analysis of sequence, phylogeny, and molecular structure. Focus on probabilistic models and algorithms, as well as structural analysis. Extensive computer use required. Prerequisite(s): BIOE 480; and graduate or professional standing; or consent of the instructor. Recommended background: Exposure to biochemistry, molecular biology, or evolution. |
| BIOE | 582 | Computational Functional Genomics | 4 hours. | Modern statistical and computational methods relevant to functional genomics. Cell function, gene regulation and protein expression. Microarray technology and use; cluster analysis; prediction of protein function. Prerequisite(s): BIOE 480. Recommended background: Basic knowledge of probability, statistics, vector algebra, calculus and cell biology. |
| BIOE | 590 | Internship in Bioengineering | 1 TO 4 hours. | Current clinical practice experience in a health care setting culminating in a written and oral report. Satisfactory/Unsatisfactory grading only. Prerequisite(s): BIOE 430 and BIOE 431 and BIOE 479. |
| BIOE | 594 | Advanced Special Topics in Bioengineering | 1 TO 4 hours. | Systematic review of selected topics in bioengineering theory and practice. Subjects vary from year to year. May be repeated. Students may register in more than one section per term. Prerequisite(s): Consent of the instructor. |
| BIOE | 595 | Seminar on Bioengineering | 0 TO 1 hours. | Recent innovations in bioengineering theory and practice presented by invited speakers, faculty and graduate students. Satisfactory/Unsatisfactory grading only. May be repeated. Students who are presenting seminars should register for 1 hour, others for 0 hour. |
| BIOE | 596 | Independent Study | 1 TO 5 hours. | Research on special problems not included in thesis research. May be repeated. Students may register in more than one section per term. Prerequisite(s): Consent of the instructor. |
| BIOE | 598 | Masters Thesis Research | 0 TO 16 hours. | Research in MS thesis project. Satisfactory/Unsatisfactory grading only. May be repeated. Students may register in more than one section per term. |
| BIOE | 599 | PhD Thesis Research | 0 TO 16 hours. | Research in PhD thesis project. Satisfactory/Unsatisfactory grading only. May be repeated. Students may register in more than one section per term. |